{"id":146845,"date":"2022-03-20T03:50:27","date_gmt":"2022-03-19T22:20:27","guid":{"rendered":"https:\/\/infinitylearn.com\/surge\/halothane-structure-mechanism-properties-and-side-effects\/"},"modified":"2022-11-03T20:58:05","modified_gmt":"2022-11-03T15:28:05","slug":"halothane-structure-mechanism-properties-and-side-effects","status":"publish","type":"post","link":"https:\/\/infinitylearn.com\/surge\/biology\/halothane\/","title":{"rendered":"Halothane &#8211; Structure, Mechanism, Properties and Side Effects"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_37 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" style=\"display: none;\"><label for=\"item\" aria-label=\"Table of Content\"><span style=\"display: flex;align-items: center;width: 35px;height: 30px;justify-content: center;\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/label><input type=\"checkbox\" id=\"item\"><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' style='display:block'><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/infinitylearn.com\/surge\/biology\/halothane\/#What_is_Halothane\" title=\"What is Halothane?\">What is Halothane?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/infinitylearn.com\/surge\/biology\/halothane\/#Halothane_Structure\" title=\"Halothane Structure\">Halothane Structure<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/infinitylearn.com\/surge\/biology\/halothane\/#Halothane_Mechanism_of_Action\" title=\"Halothane Mechanism of Action\">Halothane Mechanism of Action<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/infinitylearn.com\/surge\/biology\/halothane\/#How_is_the_Administration_of_Halothane_Done\" title=\"How is the Administration of Halothane Done?\">How is the Administration of Halothane Done?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/infinitylearn.com\/surge\/biology\/halothane\/#Role_of_Halothane_as_an_Anesthesia_Agent\" title=\"Role of Halothane as an Anesthesia Agent\">Role of Halothane as an Anesthesia Agent<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/infinitylearn.com\/surge\/biology\/halothane\/#Action_of_Halothane_on_Respiratory_Route\" title=\"Action of Halothane on Respiratory Route\">Action of Halothane on Respiratory Route<\/a><ul class='ez-toc-list-level-3'><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/infinitylearn.com\/surge\/biology\/halothane\/#Duration_of_Halothane_Action\" title=\"Duration of Halothane Action\">Duration of Halothane Action<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/infinitylearn.com\/surge\/biology\/halothane\/#Uses_for_Halothane\" title=\"Uses for Halothane\">Uses for Halothane<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/infinitylearn.com\/surge\/biology\/halothane\/#Recovery_from_Halothane\" title=\"Recovery from Halothane\">Recovery from Halothane<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/infinitylearn.com\/surge\/biology\/halothane\/#Properties_of_Halothane\" title=\"Properties of Halothane\">Properties of Halothane<\/a><ul class='ez-toc-list-level-4'><li class='ez-toc-heading-level-4'><ul class='ez-toc-list-level-4'><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/infinitylearn.com\/surge\/biology\/halothane\/#Hepatotoxicity_of_Halothane\" title=\"Hepatotoxicity of Halothane\">Hepatotoxicity of Halothane<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/infinitylearn.com\/surge\/biology\/halothane\/#Mechanism_of_Oxidative_Degradation_of_Halothane_and_Protein_Modification\" title=\"Mechanism of Oxidative Degradation of Halothane and Protein Modification\">Mechanism of Oxidative Degradation of Halothane and Protein Modification<\/a><ul class='ez-toc-list-level-4'><li class='ez-toc-heading-level-4'><ul class='ez-toc-list-level-4'><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/infinitylearn.com\/surge\/biology\/halothane\/#Role_of_Halothane\" title=\"Role of Halothane\">Role of Halothane<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/infinitylearn.com\/surge\/biology\/halothane\/#Synthesis_of_Halothane\" title=\"Synthesis of Halothane\">Synthesis of Halothane<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/infinitylearn.com\/surge\/biology\/halothane\/#Side_Effects_of_Halothane\" title=\"Side Effects of Halothane\">Side Effects of Halothane<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"What_is_Halothane\"><\/span>What is Halothane?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Halothane &#8211; Structure: <a href=\"https:\/\/infinitylearn.com\/surge\/biology\/halothane\/\">Halothane<\/a> is a general anesthetic agent that is used to produce anesthesia. It is a colorless, sweet-smelling liquid that is soluble in water. Halothane is administered by inhalation. It depresses the central nervous system and produces a state of unconsciousness.<\/p>\n<p><img loading=\"lazy\" class=\"aligncenter wp-image-146844 size-full\" src=\"https:\/\/infinitylearn.com\/surge\/wp-content\/uploads\/2022\/03\/halothane-structure-mechanism-properties-and-side-effects.jpg\" alt=\"Halothane - Structure, Mechanism, Properties and Side Effects\" width=\"606\" height=\"428\" srcset=\"https:\/\/infinitylearn.com\/surge\/wp-content\/uploads\/2022\/03\/halothane-structure-mechanism-properties-and-side-effects.jpg?v=1647728424 606w, https:\/\/infinitylearn.com\/surge\/wp-content\/uploads\/2022\/03\/halothane-structure-mechanism-properties-and-side-effects-300x212.jpg?v=1647728424 300w\" sizes=\"(max-width: 606px) 100vw, 606px\" \/><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Halothane_Structure\"><\/span>Halothane Structure<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Halothane is a haloalkane with the chemical formula C2HBrClF. It is a colorless, sweet-smelling liquid that is slightly soluble in water. Halothane is used as a general anesthetic in medical procedures. It works by depressing the central nervous system, which causes a person to lose consciousness.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Halothane_Mechanism_of_Action\"><\/span>Halothane Mechanism of Action<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Halothane alters the permeability of the lipid bilayer of the nerve cell membrane, thereby altering the membrane potential. This leads to a decrease in the release of excitatory neurotransmitters, such as glutamate, from the nerve terminal. Additionally, halothane blocks the voltage-gated Na+ channels, which leads to a decrease in the influx of Na+ ions into the nerve cell. This also contributes to the decrease in the release of excitatory neurotransmitters.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"How_is_the_Administration_of_Halothane_Done\"><\/span>How is the Administration of Halothane Done?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>When an anesthesiologist wants to administer halothane, they will first need to set up an intravenous (IV) line. Once the line is in place, they will then inject a small amount of the anesthetic into the IV. This will allow them to monitor the patient&#8217;s reaction to the anesthetic and make any necessary adjustments. Once the patient is stable, the anesthesiologist will then give the patient the remainder of the halothane through the IV.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Role_of_Halothane_as_an_Anesthesia_Agent\"><\/span>Role of Halothane as an Anesthesia Agent<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Halothane is a potent general anesthetic agent that is used to produce anesthesia. It acts by depressing the central nervous system, which leads to a decrease in the activity of the brain and spinal cord. This results in a reduction in the ability to feel pain, as well as a loss of consciousness. Halothane administered by inhalation and is very effective in providing anesthesia for short surgical procedures. It also used for longer procedures, but may cause some side effects, such as nausea and vomiting.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Action_of_Halothane_on_Respiratory_Route\"><\/span>Action of Halothane on Respiratory Route<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Halothane is a general anaesthetic agent that depresses the central nervous system and produces anaesthesia. It is a volatile liquid that is administered by <a href=\"https:\/\/en.wikipedia.org\/wiki\/Inhalation\">inhalation<\/a>. Halothane is a non-competitive inhibitor of the enzyme cytochrome c oxidase in the respiratory chain, which results in a decrease in the rate of respiration. In addition, halothane decreases the release of carbon dioxide from the tissues, which further reduces the respiratory rate.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Duration_of_Halothane_Action\"><\/span>Duration of Halothane Action<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>The half-life of halothane about 2.5 hours. This means that the concentration of halothane in the blood will  reduced by half every 2.5 hours<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Uses_for_Halothane\"><\/span>Uses for Halothane<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li>halothane is a general anesthetic that used to produce anesthesia in humans and animals.<\/li>\n<li>It also used to relieve pain and to relax muscles.<\/li>\n<li>Halothane used as a general anesthetic.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Recovery_from_Halothane\"><\/span>Recovery from Halothane<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Anesthesia in Rats<\/p>\n<ul>\n<li>A rat anesthetized with halothane.<\/li>\n<li>After a predetermined time, the rat recovered from anesthesia.<\/li>\n<li>The rat&#8217;s ability to move and also respond to stimuli assessed.<\/li>\n<li>The rat&#8217;s breathing and heart rate monitored.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Properties_of_Halothane\"><\/span>Properties of Halothane<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li>Halothane is a colorless, non-flammable, and nonexplosive gas with a slightly sweet odor.<\/li>\n<li>It is soluble in water and ether.<\/li>\n<li>halothane is a colorless liquid with a slightly sweet odor.<\/li>\n<li>It is very soluble in water and ether and slightly soluble in alcohol. halothane is a nonflammable, also nonexplosive agent.<\/li>\n<\/ul>\n<h4><span class=\"ez-toc-section\" id=\"Hepatotoxicity_of_Halothane\"><\/span>Hepatotoxicity of Halothane<span class=\"ez-toc-section-end\"><\/span><\/h4>\n<p>The hepatotoxicity of halothane is a result of the induction of hepatic microsomal enzymes. These enzymes can also produce toxic metabolites from halothane that can damage the liver.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Mechanism_of_Oxidative_Degradation_of_Halothane_and_Protein_Modification\"><\/span>Mechanism of Oxidative Degradation of Halothane and Protein Modification<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Halothane undergoes oxidative degradation to yield carbon dioxide, nitrogen oxide, and hydrogen fluoride. The nitrogen oxide and hydrogen fluoride can react with water to form nitric acid and hydrofluoric acid, respectively. These acidic compounds can then attack the protein in the anesthesia machine and cause it to degrade.<\/p>\n<p>Involvement of the Trifluoroacetyl Chloride Metabolite of Trichlorfon in the Inhibition of Acetylcholinesterase. Therefore the trifluoroacetyl chloride metabolite of trichlorfon is a potent inhibitor of acetylcholinesterase.<\/p>\n<h4><span class=\"ez-toc-section\" id=\"Role_of_Halothane\"><\/span>Role of Halothane<span class=\"ez-toc-section-end\"><\/span><\/h4>\n<p>Halothane a general anesthetic that used to put people to sleep for surgery. It works by depressing the central nervous system.<\/p>\n<h4><span class=\"ez-toc-section\" id=\"Synthesis_of_Halothane\"><\/span>Synthesis of Halothane<span class=\"ez-toc-section-end\"><\/span><\/h4>\n<p>Halothane synthesized by the reaction of ethylene oxide with sulfuric acid:<\/p>\n<p>2CH2=CH2 + H2SO4 \u2192 2CH2ClCH2SO4<\/p>\n<p>The product is purified by distillation.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Side_Effects_of_Halothane\"><\/span>Side Effects of Halothane<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The most common side effects of halothane are nausea, vomiting, and also feeling of warmth.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>What is Halothane? Halothane &#8211; Structure: Halothane is a general anesthetic agent that is used to produce anesthesia. It is [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_yoast_wpseo_focuskw":"Halothane - Structure","_yoast_wpseo_title":"%%title%% %%page%%","_yoast_wpseo_metadesc":"Learn about halothane topic of Biology in details explained by subject experts on infinitylearn.com. Register free for online session","custom_permalink":"biology\/halothane\/"},"categories":[11],"tags":[],"table_tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v17.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Halothane - Structure, Mechanism, Properties and Side Effects<\/title>\n<meta name=\"description\" content=\"Learn about halothane topic of Biology in details explained by subject experts on infinitylearn.com. 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