{"id":148971,"date":"2022-03-21T09:50:56","date_gmt":"2022-03-21T04:20:56","guid":{"rendered":"https:\/\/infinitylearn.com\/surge\/antimetabolite-meaning-classification-function-uses-and-faqs\/"},"modified":"2024-12-16T10:44:00","modified_gmt":"2024-12-16T05:14:00","slug":"antimetabolite-meaning-classification-function-uses-and-faqs","status":"publish","type":"post","link":"https:\/\/infinitylearn.com\/surge\/chemistry\/antimetabolite\/","title":{"rendered":"Antimetabolite &#8211; Meaning, Classification, Function, Uses and FAQs"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_37 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" style=\"display: none;\"><label for=\"item\" aria-label=\"Table of Content\"><span style=\"display: flex;align-items: center;width: 35px;height: 30px;justify-content: center;\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/label><input type=\"checkbox\" id=\"item\"><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' style='display:block'><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/infinitylearn.com\/surge\/chemistry\/antimetabolite\/#What_are_Antimetabolites_Types_of_Chemotherapy_Function_of_Antimetabolites\" title=\"What are Antimetabolites? ; Types of Chemotherapy ; Function of Antimetabolites\">What are Antimetabolites? ; Types of Chemotherapy ; Function of Antimetabolites<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/infinitylearn.com\/surge\/chemistry\/antimetabolite\/#Some_Antimetabolite_Drugs_are\" title=\"Some Antimetabolite Drugs are:\">Some Antimetabolite Drugs are:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/infinitylearn.com\/surge\/chemistry\/antimetabolite\/#Antimetabolites_Mechanism_of_Action\" title=\"Antimetabolites Mechanism of Action\">Antimetabolites Mechanism of Action<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/infinitylearn.com\/surge\/chemistry\/antimetabolite\/#Category_of_Antimetabolites_on_the_Basis_of_Analogues\" title=\"Category of Antimetabolites on the Basis of Analogues\">Category of Antimetabolites on the Basis of Analogues<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/infinitylearn.com\/surge\/chemistry\/antimetabolite\/#Further_Classification_of_Antimetabolite_Drugs\" title=\"Further Classification of Antimetabolite Drugs\">Further Classification of Antimetabolite Drugs<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/infinitylearn.com\/surge\/chemistry\/antimetabolite\/#Antitumor_Antibiotics\" title=\"Antitumor Antibiotics\">Antitumor Antibiotics<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/infinitylearn.com\/surge\/chemistry\/antimetabolite\/#Antimetabolites_and_Immunosuppressive_Agents\" title=\"Antimetabolites and Immunosuppressive Agents\">Antimetabolites and Immunosuppressive Agents<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/infinitylearn.com\/surge\/chemistry\/antimetabolite\/#Antibiotics\" title=\"Antibiotics\">Antibiotics<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/infinitylearn.com\/surge\/chemistry\/antimetabolite\/#Other_Uses_of_Antimetabolites\" title=\"Other Uses of Antimetabolites\">Other Uses of Antimetabolites<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"What_are_Antimetabolites_Types_of_Chemotherapy_Function_of_Antimetabolites\"><\/span>What are Antimetabolites? ; Types of Chemotherapy ; Function of Antimetabolites<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Antimetabolites are drugs that interfere with the function of enzymes involved in the synthesis of DNA and RNA. Antimetabolites are used in chemotherapy to kill cancer cells. There are two types of chemotherapy: alkylating agents and antimetabolites. Alkylating agents work by damaging the DNA of cancer cells. Antimetabolites work by interfering with the enzymes that are involved in the synthesis of DNA and RNA. Antimetabolite &#8211; Meaning Classification Function Uses and FAQs.<\/p>\n<p><img loading=\"lazy\" class=\"aligncenter wp-image-148970 size-full\" src=\"https:\/\/infinitylearn.com\/surge\/wp-content\/uploads\/2022\/03\/antimetabolite-meaning-classification-function-uses-and-faqs.jpg\" alt=\"Antimetabolite - Meaning, Classification, Function, Uses and FAQs\" width=\"606\" height=\"428\" srcset=\"https:\/\/infinitylearn.com\/surge\/wp-content\/uploads\/2022\/03\/antimetabolite-meaning-classification-function-uses-and-faqs.jpg?v=1647836451 606w, https:\/\/infinitylearn.com\/surge\/wp-content\/uploads\/2022\/03\/antimetabolite-meaning-classification-function-uses-and-faqs-300x212.jpg?v=1647836451 300w\" sizes=\"(max-width: 606px) 100vw, 606px\" \/><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Some_Antimetabolite_Drugs_are\"><\/span>Some Antimetabolite Drugs are:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Folic acid antagonists: Methotrexate, Pemetrexed<\/p>\n<p>Purine analogs: Azathioprine, 6-mercaptopurine<\/p>\n<p>Pyrimidine analogs: Trimethoprim-sulfamethoxazole, Fluorouracil<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Antimetabolites_Mechanism_of_Action\"><\/span>Antimetabolites Mechanism of Action<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Antimetabolites are drugs that interfere with the metabolism of cells. They are structurally similar to important cellular metabolites, but they are not recognized by the enzymes that normally catalyze their formation. As a result, the cells are unable to synthesize the normal metabolites, and they die.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Category_of_Antimetabolites_on_the_Basis_of_Analogues\"><\/span>Category of Antimetabolites on the Basis of Analogues<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>There are several types of antimetabolites, which can be broadly classified on the basis of their chemical structure and their function within the cell.<\/p>\n<p>The most common type of antimetabolite is the analog, which is structurally similar to a naturally occurring molecule but has a different function. For example, the antimetabolite methotrexate is structurally similar to the naturally occurring molecule folic acid, but it blocks the action of folic acid in the cell.<\/p>\n<p>Another type of antimetabolite is the inhibitor, which blocks the action of a specific enzyme within the cell. For example, the antimetabolite azathioprine blocks the action of the enzyme thiopurine methyltransferase, which is involved in the synthesis of purines.<\/p>\n<p>The final type of antimetabolite is the suicide inhibitor, which is structurally similar to a naturally occurring molecule but has an altered function that causes the molecule to self-destruct. For example, the antimetabolite 5-fluorouracil is structurally similar to the naturally occurring molecule uracil, but it is converted into a toxic molecule that damages the cell.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Further_Classification_of_Antimetabolite_Drugs\"><\/span>Further Classification of Antimetabolite Drugs<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>There are different types of antimetabolite drugs. The most common type of antimetabolite drug is the antibiotic drug. Antibiotic drugs are used to treat bacterial infections. Antibiotic drugs work by killing the bacteria that are causing the infection.<\/p>\n<p>Other types of antimetabolite drugs include:<\/p>\n<p>Chemotherapy drugs: Chemotherapy drugs are used to treat cancer. Chemotherapy drugs work by killing the cancer cells that are causing the cancer.<\/p>\n<p>Hormone therapy drugs: Hormone therapy drugs are used to treat cancer. Hormone therapy drugs work by blocking the hormones that are helping the cancer cells to grow.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Antitumor_Antibiotics\"><\/span>Antitumor Antibiotics<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Anthracyclines: daunorubicin, doxorubicin, epirubicin<\/p>\n<p>Plicamycin: Mithracin<\/p>\n<p>Dactinomycin: Actinomycin D<\/p>\n<p>Bleomycin: Bleomycin sulfate<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Antimetabolites_and_Immunosuppressive_Agents\"><\/span>Antimetabolites and Immunosuppressive Agents<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The potential for additive or synergistic toxicity between antimetabolites and immunosuppressive agents must be considered when treating patients with both types of agents.<\/p>\n<p>The combination of methotrexate and leflunomide is an example of an additive toxicity. If a patient is being treated with both agents, the dose of each should be reduced.<\/p>\n<p>The combination of mycophenolate mofetil and azathioprine is an example of a synergistic toxicity. If a patient is being treated with both agents, the dose of each should be increased.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Antibiotics\"><\/span>Antibiotics<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>If you have an infection, your doctor may prescribe antibiotics. Antibiotics are a type of medication that kills bacteria.<\/p>\n<p>There are many different types of antibiotics. Your doctor will prescribe the antibiotic that is most likely to work against the bacteria causing your infection.<\/p>\n<p>It is important to take antibiotics exactly as prescribed. If you do not take them all, the infection may not go away. If you stop taking them too soon, the infection may come back.<\/p>\n<p>Some common side effects of antibiotics include nausea, vomiting, and diarrhea. If you experience any of these side effects, tell your doctor.<\/p>\n<p>Do not take antibiotics if you are pregnant or breastfeeding, unless your doctor tells you to.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Other_Uses_of_Antimetabolites\"><\/span>Other Uses of Antimetabolites<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Some antimetabolites are also used as cancer treatments. Methotrexate is a common example. It is used to treat a variety of cancers, including leukemia, breast cancer, and lung cancer. Antimetabolite &#8211; Meaning Classification Function Uses and FAQs.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>What are Antimetabolites? ; Types of Chemotherapy ; Function of Antimetabolites Antimetabolites are drugs that interfere with the function of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_yoast_wpseo_focuskw":"Antimetabolite - Meaning Classification Function Uses and FAQs","_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"Learn about Antimetabolite - Meaning Classification Function Uses and FAQs by subject experts on infinitylearn.com.","custom_permalink":"chemistry\/antimetabolite\/"},"categories":[1],"tags":[],"table_tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v17.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Antimetabolite - Meaning, Classification, Function, Uses and FAQs - Infinity Learn by Sri Chaitanya<\/title>\n<meta name=\"description\" content=\"Learn about Antimetabolite - 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