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By Shailendra Singh
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Updated on 2 Jan 2025, 18:08 IST
The pancreas is a stomach organ surrounded by the spleen, liver, and small intestines and located behind the abdomen. It is an important part of the digestive system that regulates blood sugar levels.
The pancreas secretes digestive juices from the duodenum. Sugar, protein, and lipids are all broken down by these enzymes. In addition, the Langerhans are found in the arteries and release hormones such as insulin and glucagon into the bloodstream.
The pancreas is a long gland that produces the digestive tract in the small intestine and is located at the back of the abdomen. The pancreas is found in the back of the abdomen and in front of the spine.
The head of your pancreas is located to the right of your body. The duodenum, the first part of your small intestine, contains this tiny organ. The tail of your pancreas is located on the left side of your body.
Tail: The tail of the pancreas is the smallest part of the organ, located near the spleen.
The pancreas is responsible for the following functions:
The work of the Exocrine Gland: The pancreas is made up of exocrine glands that produce digestive enzymes trypsin and chymotrypsin. These enzymes include chymotrypsin and trypsin for digestion of protein, amylase for digestion of carbohydrates, and lipase for digestion of fats. These pancreas secretions are released into the duct system as food enters the stomach, reaching the climax of the pancreatic duct.
Endocrine Activity: The Langerhans Islands, located in the endocrine portion of the pancreas, release insulin and glucagon directly into the bloodstream. They help regulate the body’s blood sugar levels.
Inside your pancreas, various cell types form hormones. Hormones that are released into your bloodstream and transmit messages to different parts of your digestive system, unlike enzymes, are delivered to your digestive system.
For example, the pancreas produces the following hormones:
Gastrin and amylin. Gastrin is produced primarily by G cells in the stomach, and it is produced in the pancreas. It stimulates the production of gastric acid in your stomach. Amylin is a product of beta cells that help regulate appetite and digestion.
Pancreatic juice is a combination of digestive enzymes produced in the pancreas. The following are some of them:
Trypsinogen: A protein produced by the digestive enzyme trypsin. The enzyme enterokinase converts the inactive protease into trypsin. Trypsin, on the other hand, is responsible for breaking down proteins into amino acids.
Chymotrypsinogen: Enterokinase or trypsin enzymes activate this quiet protease, converting it to chymotrypsin. Chymotrypsin, on the other hand, is responsible for breaking down proteins into fragrant amino acids.
Carboxypeptidase: A protease responsible for breaking down proteins into amino acids.
Pancreatic diseases may be difficult to diagnose due to the inaccessibility of the pancreas. Precancerous conditions, pancreatitis, and pancreatic cancer are all disorders that affect the pancreas. Each condition has its own set of symptoms and requires its own set of treatments.
There are two types of pancreatitis, depending on their pathogenesis. Acute pancreatitis is a type of pancreatitis that occurs suddenly and lasts only a few days. When proper health care is provided, the condition usually disappears within a few days.
Alternatively, chronic pancreatitis is more likely to occur after a painful episode of pancreatitis. It is a long-term condition that can last for several years. Alcohol use, diseases, medications, gallstones, autoimmune diseases, trauma, and surgery are some of the most common causes of pancreatitis.
When a person has pancreatitis, they often have pain in the upper abdomen. Depending on the condition, the pain may be immediate or severe. The discomfort disappears when you eat something, but it can get worse. In many cases, there is also pain in the gallbladder and ulcer. Abdominal discomfort is a symptom of inflammation of the acute pancreas. However, in the event of chronic pancreatitis, the patient may not feel any discomfort at all.
Exocrine glands in the pancreas form enzymes that help digest food. These enzymes include trypsin and chymotrypsin for digestion of protein, amylase for digestion of carbohydrates, and lipase for digestion of fats.
Digestive enzymes and bicarbonate are two secret products found in pancreatic juice that are essential for digesting active food. Exocrine acinar cells produce and release enzymes, while epithelial cells around the pancreatic ducts produce bicarbonate.
Pancreas and liver produce pancreatic and gallbladder juice, which aids digestion (i.e., the breakdown of food into portions that can be easily absorbed and used by the body).
The presence of lightly digested proteins and lipids in the small intestine promotes its release. Cholecystokinin is released into the bloodstream as the chyme enters the small intestine and attaches itself to receptors in pancreatic acinar cells, commanding it to release large amounts of digestive enzymes.
Insulin is produced by beta cells in your pancreas due to elevated blood sugar levels. For example, any carbohydrates you eat are broken down into sugars and sent to your bloodstream after eating. When the pancreas sees an increase in blood glucose, it begins to produce insulin.