First slide

M Phase

Question

Which of the following event is not done if Anaphase promoting complex (APC) is not formed?

Moderate

A

$G_{1}$ to S transition
B

Separation of sister chromatids.
C

$G_{2}$ to M transition
D

S to $G_{2}$ transition

Solution

The anaphase promoting complex is involved in separation of the sister chromatids.
APC becomes activated prior to metaphase and ubiquitinates a key anaphase inhibitor called securin —so named because it secures the attachment between sister chromatids. The ubiquitination and destruction of securin at the end of metaphase release an active protease called separase. Separase then cleaves the a subunit of the cohesin molecule that holds sister chromatids together. Cleavage of cohesin by such enzymes leads rapidly to the separation of chromatids and their anaphase movement towards the poles.

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