[[1]] was the most powerful biological weapon that the Spanish used to conquer America.

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Detailed Solution

Smallpox was the most powerful biological weapon that the Spanish used to conquer America. Spain established its hegemony in the American territories. Spain did not use any conventional weapon to conquer these territories. Rather it utilised germs as the most potent weapon. The American natives lived in isolation from the external world. The Spanish carried germs (smallpox) to America. As Americans were not immune to smallpox, it affected the native population. As a result, the native population declined, which paved the way for the conquest.

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