Q.

A disease caused by an autosomal primary non­ disjunction is

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a

Klinefelter's syndrome

b

Turner's syndrome

c

sickle cell anaemia

d

Down's syndrome

answer is D.

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Detailed Solution

Failure of segregation of chromatids during the cell division cycle results in the gain or loss of a chromosome(s), called aneuploidy. Example- Down’s syndrome results in the gain of an extra copy of chromosome-21. Sickle-cell anemia is caused due to change of one base in the gene coding for the beta-chain of hemoglobin.

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