A man with a certain Mendelian disorder marries a normal (homozygous) woman. All his five daughters are affected but none of his five sons is affected with the disease. The mode of inheritance of the disease is

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A man with a certain Mendelian disorder marries a normal (homozygous) woman. All his five daughters are affected but none of his five sons is affected with the disease. The mode of inheritance of the disease is

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X-linked recessive

X-linked dominant

Y-linked

Autosomal recessive

answer is B.

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Detailed Solution

A male child inherits X chromosome only from his mother. A female child inherits one X chromosome from each parent. If a man passes his X chromosome to each of his daughters. If he has a dominant allele that causes a disorder on his single X chromosome, it will be inherited by all his daughters who would eventually exhibit the disorder.
A daughter would exhibit an X-linked recessive disorder only when her mother is at least a carrier and father is affected. Y-linked disorders are seen only in males. If the woman is homozygous dominant, none of the children would suffer from the disorder.

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