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Q.

(A) Non-competitive inhibitors occupy allosteric site so that the substrate cannot attach at active site.
(R) Non-competitive inhibitors change the shape of active site of enzyme after binding at allosteric site.

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a

Both (A) and (R) are true and (R) is the correct explanation of (A)

b

Both (A) and (R) are true and (R) is not the correct explanation of (A)

c

(A) is true but (R) is false

d

Both (A) and (R) are false

answer is A.

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Detailed Solution

  • In non-competitive inhibition, an inhibitor molecule binds to the enzyme at a location other than the active site (an allosteric site). 
  • The substrate can still bind to the enzyme, but the inhibitor changes the shape of the enzyme so it is no longer in an optimal position to catalyze the reaction.
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