A pedigree is shown below for a disease that is autosomal dominant.
By observing the above, identify the correct with respect to II and III generation offspring.

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II – 2 is carrier

II – 5 is homozygous affected

III – 3 is heterozygous affected

III – 5 is homozygous affected

answer is C.

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Detailed Solution

III - 3 is heterozygous affected since the male parent is normal (homozygous recessive)

II – 2 is normal (homozygous recessive)

II – 5 is heterozygous since the male parent is normal (homozygous recessive)

III – 5 is heterozygous affected since the male parent is normal (homozygous recessive)

A carrier is an organism which carries an allele (recessive allele) without expressing it. One cannot carry dominant alleles without expressing.

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