Amino acid substituted in sickle – cell anaemia at

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8^th position of $β$ -chain

None of the above

7^th position of $β$ -chain

6^th position of $β$ -chain

answer is B.

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Detailed Solution

Sickle cell anemia is a blood related defect caused by the substitution of Glutamic acid (Glu) by Valine (Val) at the sixth position of the beta globin chain of the haemoglobin molecule.

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