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Q.

Amitriptyline, sold under the brand name Elavil is a tricyclic antidepressant. The flowchart below outlines its chemical synthesis.

Question Image

Select the correct statement(s) :

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a

Question Image  MgI is a possible Grignard reagent in step-1 followed by acid workup

b

Step-2 involves the formation of a highly stable carbocation intermediate

c

a primary carbocation is not formed as an intermediate at any point during the drug making

d

diethyl amine attacks in an  SN2 manner in step-3 

answer is A, B, C.

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Amitriptyline, sold under the brand name Elavil is a tricyclic antidepressant. The flowchart below outlines its chemical synthesis.Select the correct statement(s) :