Anaphase Promoting Complex (APC) is a protein degradation machinery necessary for proper mitosis of animal cell. If APC is defective in a human cell, which of the following is expected to occur?

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Chromosomes will be fragmented.

Recombination of chromosome arms will occur.

Chromosomes will not segregate.

Chromosomes will not condense.

answer is B.

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Detailed Solution

If anaphase promoting complex or APC is inactive or defective, the chromosomes will not segregate because the cohesins present between sister chromatids, which hold them together, are not degenerated.
APC is activated only after attachment of spindle fibres to kinetochores of all chromosomes is completed.
(1) Defective APC does not promote chromosomal fragmentation.
(3) Defective APC has no role in recombination of chromosomal arms. Recombination is an event of pachytene of prophase I of meiosis I.
(4) Defective APC has no role in chromosomal condensation.

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