Assertion (A): TCA cycle required the continuous replenishment of OAA.
Reason(R): OAA is the first member of cycle.

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Both (A) and (R) are true and (R) is the correct explanation of (A)

Both (A) and (R) are true and (R) is not the correct explanation of (A)

(A) is true but (R) is false

Both (A) and (R) are false

answer is A.

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Detailed Solution

Assertion is true. OAA is the starting compound in the TCA cycle and combines with acetyl-CoA to initiate the cycle. As the cycle progresses, OAA is gradually consumed and converted into other intermediate compounds, and it must be replenished to sustain the cycle. OAA is regenerated through various reactions, such as the conversion of malate to OAA, which is an essential step for maintaining the continuity of the cycle.

Reason is also true. In the first step of the TCA cycle, acetyl-CoA, derived from various metabolic pathways, combines with OAA to form citrate. Thus, OAA is the first compound to participate in the TCA cycle, and the entire cycle revolves around its continuous regeneration.

Both (A) and (R) are true and (R) is the correct explanation of (A).

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