Choose the appropriate reagent sequence from the given reagent pool to complete the synthetic conversion. Make sure to use strictly four reagents, not more not less.
Note: You can simply mention the numerical values corresponding to the reagent in the boxes P, Q, R and S respectively and also consider major organic product in each step. What is the value of [P + R + S – Q]?

 

 

 

 

 

1.  $HBr$                                 2. $H^{+}/H_{2}O$                      3. $Hg{\left(OAc\right)}_2{H}_{2}O$                4.  $B{H}_3.THF$
5. $EtONa/EtOH/\Delta$       6. $HBr/ROOR/\Delta$         7.  $conc.H_{2}S{O}_4/\Delta$             8. $NaB{H}_4$ 

9. $H_2{O}_{2,}aq.NaOH$         10. $t-BuOK/\Delta$

Chemical Reaction Explanation

The image shows a chemical reaction involving the conversion of an alkene into an alcohol. Here's the explanation:

1. Starting Material:

   The reactant is a branched alkene with a double bond between the terminal carbon and the adjacent carbon.

2. Reagents:
   • HBr/ROOR/Δ: This step likely introduces a bromine atom to the less substituted carbon of the double bond (anti-Markovnikov addition of HBr).
   • t-BuOK/Δ: This strong base induces elimination (E2 mechanism) to regenerate a terminal alkene.
   • BH₃·THF: Hydroboration adds boron to the less substituted carbon and hydrogen to the more substituted carbon in a syn-addition manner.
   • H₂O₂/aq. NaOH: Oxidation of the boron intermediate replaces the boron with a hydroxyl (-OH) group, forming an alcohol.

3. Product:

   The final product is a secondary alcohol located on a branched alkane, indicating anti-Markovnikov addition of water across the initial double bond.

This sequence of reactions effectively transforms the starting alkene into a terminal alcohol through a combination of hydroboration and oxidation.