Choose the correct statement related to sickle cell anaemia.

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It is an X-linked recessive trait.

It is caused by the substitution of Glutamic acid by Valine at the sixth position of the beta globin chain of the haemoglobin molecule.

It is controlled by two closely linked genes HBA1 and HBA2 on chromosome 16.

The mutant haemoglobin molecule undergoes polymerisation under high oxygen tension causing the RBC to become sickle-shaped.

answer is B.

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Detailed Solution

Sickle cell anaemia is caused by the substitution of Glutamic acid by Valine at the sixth position of the beta globin chain of the haemoglobin molecule.

It is an autosomal recessive trait. It is controlled by HBB gene on chromosome 11. The mutant haemoglobin molecule undergoes polymerisation under low oxygen tension.

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