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Q.

Choose the incorrect statement.

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a

Sickle cell anemia is a disease developed due to point mutation.

b

All point mutations are frame shift mutations.

c

All frame shift mutations are point mutations

d

Sickle cell anemia is due to change in the amino acid residue glutamate to valine in the beta globin chain of hemoglobin of RBC of man.

answer is B.

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Detailed Solution

Not all point mutations are frameshift mutations. Some point mutations are substitution mutations. Frame shift mutations are due to deletion or addition of one or two or four or five base pairs within a gene but not deletion or addition of three or multiples of thee base pairs. Sickle cell anemia is due to substitution transversion mutations. It is a missense mutation. 

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