Choose the incorrect statement related to DNA replication.

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DNA polymerase can initiate DNA replication.

Replication does not initiate randomly at any place in DNA.

There is a definite region in E.coli where replication originates called origin of replication.

The discontinuously synthesised fragments are joined by DNA ligase.

answer is A.

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Detailed Solution

DNA polymerase cannot initiate DNA replication on its own. DNA replication is a highly regulated and coordinated process in which DNA polymerase plays a central role in extending an existing DNA strand but cannot start a new strand from scratch.

To initiate DNA replication, a separate enzyme called primase is required. Primase synthesizes a short RNA primer complementary to the DNA template strand.

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