Choose the incorrect statement related to DNA replication.

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DNA polymerase can initiate DNA replication.

There is a definite region in E.coli where replication originates called origin of replication.

The discontinuously synthesised fragments are joined by DNA ligase.

Replication does not initiate randomly at any place in DNA.

answer is A.

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Detailed Solution

DNA polymerase cannot initiate DNA replication on its own. DNA replication is a highly regulated and coordinated process in which DNA polymerase plays a central role in extending an existing DNA strand but cannot start a new strand from scratch.

To initiate DNA replication, a separate enzyme called primase is required. Primase synthesizes a short RNA primer complementary to the DNA template strand.

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