Choose the word/ phrase which is opposite in meaning to the italicized bold word/ phrase in the sentence.
The drug will have pernicious effect on your health.

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beneficial

answer is A.

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Pernicious means having an unfavorable or a negative effect. It is an adjective.
Option A: Beneficial means having a positive or favorable effect. it's an adjective.
For example: Following a healthy routine is helpful for your health.
We observe that it means the precise opposite of pernicious. We will conclude that option ‘A’ is the correct answer.
Option B: Prolonged means lengthy or stretched for a substantial amount of your time. it's an adjective.
For example, There was a chronic silence within the room.
We observe that it does mean the alternative of pernicious. So, we are able to say that option B isn't the right answer.
Option C: Ruinous means having the power to cause a disaster or being destructive. it's an adjective.
For example, The miscalculated move proved to be ruinous to several
We observe that it does mean the alternative of pernicious. So, we are able to say that option C isn't the right answer.
Option D: Pertinent means having relevance or being applicable to a specific matter. it's an adjective.
For example, One must explore pertinent issues.
We observe that it does mean the other of pernicious. Hence, we will say that option D isn't the right answer.
Hence, option A is the correct answer.