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Q.

Describe erythroblastosis foetalis.

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Detailed Solution

  • Erythroblastosis foetalis is an alloimmune condition. It develops in Rh positive foetus whose father is Rh positive and mother is Rh negative.
  • The foetal blood cells pass through the ruptured placenta into the mother’s Rh-negative blood during childbirth.
  • Mother’s immune system identifies Rh positive antigens of foetal RBC and produces Rh antibodies.
  • Rh antibodies pass through placenta, enter the foetal circulation and destroy the blood cells of foetus causing erythroblastosis foetalis.
  • Haemolytic anaemia and jaundice are the symptoms of the disease.
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