DNA is a polymer of nucleotides which are linked to each other by 3'-5'phosphodiester bond. To prevent polymerisation of nucleotides, which of the following modifications would you choose?

To prevent polymerisation of nucleotides, 3' OH group in deoxyribose should be replaced/removed. this is because DNA polymerase enzyme requires a free 3'-OH end of pre-existing polynucleotide to enable polymerisation, leading to the formation of a continuous strand in the 5' → 3' direction.