Q.

Erythroblastosis foetalis can be prevented by administering anti-Rh antibodies to the Rh-ve mother immediately after the delivery of the first Rh +ve child because

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a

the injected anti-Rh antibodies provide active immunisation to the mother

b

the mother's immune system cannot produce antibodies by itself

c

the injected anti-Rh antibodies prevent sensitisation of the mother's immune system

d

anti-Rh antibodies cannot cross the placenta as they are large in size

answer is C.

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Detailed Solution

Erythroblastosis foetalis can be prevented by administering anti-Rh antibodies to the mother immediately after the delivery of the first child. These antibodies bind to and inactivate the fetal Rh antigens before the mother’s immune system can respond to the foreign antigens by producing her own anti-Rh antibodies. This is an example of passive immunisation. Anti-Rh antibodies (IgG) are small and can cross the placenta.

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