Formation of carbamino-haemoglobin occurs mainly at the

The binding of CO₂ to haemoglobin is related to the partial pressure of CO₂. pO₂ is a major factor which could affect this binding. In the tissues, where pCO^₂ is high and pO₂ is low, more binding of carbon dioxide occurs. In the alveoli where pCO₂ is low and pO₂ is high, dissociation of CO₂ from carbamino-haemoglobin into CO₂ and haemoglobin takes place and the CO₂ is delivered to the alveoli.