General mechanism for nucleophilic acyl substitution reactions of carboxylic acid derivatives is given below

For base catalysed hydrolysis of amides which is nucleophilic acyl substitution reaction, correct statement is/are

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Step- II is slower than step-I

At moderate concentration of base order of reaction is 2

Possible on prolonged heating with strong base.

When concentration of base is very high, order of reaction is 3

answer is A, B, C, D.

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Detailed Solution

Question Image
Most of the nucleophilic substitution reactions of carboxylic acid derivatives are bimolecular with the formation of tetrahedral intermediate as rate determining step But in base catalysed hydrolysis of amide, breaking down of tetrahedral intermediate is R.D.S. It is unimolecular second order. This is because $- N H_{2}^{-}$ is very bad leaving group.
$r = k$ [Tetrahedral intermediate] $= k . k_{c} {[R C O N H_{2}]}^{1} {[O H]}^{1} = K^{1} {[R C O N H_{2}]}^{1} {[O H^{-}]}^{1}$
Total O.R=2, Molecularity of R.D.S =1
When Conc. of base is very high
Question Image $r = K . K_{C} {[R C O N H_{2}]}^{1} {[O H^{-}]}^{2} = K^{1} {[R C O N H_{2}]}^{1} {[O H^{-}]}^{2}$
Molecularity of R.D.S=1, Order of reaction=3