Given below are to statements. One is labelled as Assertion (A) and the other is labelled as Reason (R).

Assertion (A): FSH, which interacts with membrane, bound receptors, does not enter the target cell. 
Reason (R):  Binding of FSH to its receptors generates second messenger (cyclic AMP) for its biochemical and physiological responses. 

In the light of the above statements, choose the most appropriate answer from the options given below.

A is true. FSH is a protein hormone. It interacts with specific receptors located on the surface of target cells. Upon binding to these receptors, it triggers a series of intracellular signaling events without entering the target cell itself.

R is true. The binding of FSH to its receptors does indeed generate the second messenger cyclic AMP (cAMP) inside the target cell. cAMP is involved in mediating various cellular responses, including the activation of protein kinases.

R does not explain A. The Reason (R) provided does not directly explain why FSH does not enter the target cell. The reason for this is that FSH, being a large protein molecule, cannot pass through the cell membrane.