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Q.

Given below are two statements. One is labelled Assertion (A) and the other is labelled Reason (R). 

Assertion (A) : The possibility of a female becoming haemophilic is extremely rare.

Reason    (R)  : Mother of a haemophilic female has to be at least a carrier and the father should be haemophilic.

In light of the above statements, choose the correct answer from the options given below. 

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a

Both (A) and (R) are true and (R) is the correct explanation of (A).

b

Both (A) and (R) are true but (R) is not the correct explanation of (A). 

c

Both (A) and (R) are false.

d

(A) is true but (R) is false.

answer is A.

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Detailed Solution

Hemophilia is an X-linked recessive genetic disorder, which means it is carried on the X chromosome. Since females have two X chromosomes (XX), they would need to inherit two copies of the hemophilia gene (one from each parent) to express the disorder.

However, it's extremely rare for females to be hemophilic because if they inherit one normal X chromosome and one X chromosome carrying the hemophilia gene, the normal gene typically compensates for the faulty gene, preventing the expression of the disorder. In such cases, females are carriers of the hemophilia gene but do not usually show symptoms.

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