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Q.

Given below are two statements.
Statement I: Griffith concluded that the R strain became virulent due to the transfer of some transforming principle from the heat attenuated S strain.
Statement II: Oswald Avery, Colin MacLeod and Maclyn McCarty experiments discovered that digestion of the heat killed S strain extract with DNase inhibited transformation.
In light of the above statements, choose the correct answer from the options given below.

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a

Statement I is incorrect but statement II is correct.

b

Both statement I and statement II are correct.

c

Statement I is correct but statement II is incorrect.

d

Both statement I and statement II are incorrect.

answer is A.

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Detailed Solution

Griffiths experiments(1928), concluded that the R strain bacteria had somehow been transformed by the heat-killed S strain bacteria and made it virulent. Some ‘transforming principle’, transferred from the heat-killed S strain, enabled the R strain to synthesize a smooth polysaccharide coat. However, the biochemical nature of genetic material was not defined by his experiments.

Oswald Avery, Colin MacLeod and Maclyn McCarty (1933-44), conducted experiments to characterise the transforming principle.

They discovered that protein-digesting enzymes (proteases) and RNA-digesting enzymes (RNases) did not affect transformation, so the transforming substance was not a protein or RNA. 

However, digestion with DNase did inhibit transformation, suggesting that the DNA caused the transformation.

Note : DNase is a DNA digesting enzyme (protein).

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