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Q.
Given below are two statements.
Statement I : Sickle cell anaemia and haemophilia are autosomal dominant traits.
Statement II : Sickle cell anaemia and haemophilia are disorders of the blood.
In the light of the above statements, choose the correct answer from the options given below.
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a
Statement I is correct but statement II is incorrect.
b
Both statement I and statement II are correct.
c
Statement I is incorrect but statement II is correct.
d
Both statement I and statement II are incorrect.
answer is D.
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Detailed Solution

Statement I is incorrect but statement II is correct.
SI: Sickle cell anaemia and haemophilia are not autosomal dominant traits. Sickle cell anaemia is an autosomal
recessive trait. An individual needs to inherit two copies of the defective gene, one from each parent, to have the disease ().
Haemophilia is an X-linked recessive trait (except for haemophilia C, which is an autosomal recessive trait). It
primarily affects males. Males have one X chromosome and one Y chromosome, and if their X chromosome carries the defective gene, they will express the disorder. Females with defective gene on a single X chromosomes are carriers of the disorder without showing symptoms. Females with defective gene on both X chromosomes are diseased.
SII: Both sickle cell anaemia and haemophilia are genetic disorders affecting the blood.
Sickle cell anaemia is characterised by abnormal haemoglobin molecules in RBCs. It is caused by a point mutation in the gene responsible for producing beta chain of haemoglobin. The mutation results in the production of abnormal haemoglobin called haemoglobin S (). When oxygen levels are low, molecules can form long, rigid structures that cause red blood cells to assume a sickle shape. These sickle-shaped cells can get stuck in blood vessels, leading to pain, organ damage, and anaemia.
Haemophilia is a genetic disorder characterised by a deficiency in blood clotting factors. The most common types are haemophilia A and haemophilia B, caused by mutations in the genes that produce clotting factor VIII and clotting factor IX, respectively. The lack of these clotting factors impairs the blood’s ability to clot, resulting in prolonged bleeding after injury.