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Q.

Given below are two statements.

Statement I : Thalassemia is a qualitative problem of globin synthesis.

Statement II : Beta thalassemia is controlled by a single gene HBB on 16th chromosome. 

In light of the above statements, choose the correct answer from the options given below.

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a

Both statement I and statement II are correct.

b

Both statement I and statement II are incorrect.

c

Statement I is correct but statement II is incorrect.
 

d

Statement I is incorrect but statement II is correct. 

answer is B.

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Detailed Solution

Both statement I and statement II are incorrect.

Statement I incorrectly states that thalassemia is a qualitative problem of globin synthesis. Thalassemia is actually a quantitative problem of globin synthesis, where there is a reduced production of one or more types of globin chains, leading to an imbalance in the alpha and beta chains of hemoglobin.

Statement II incorrectly states that beta thalassemia is controlled by a single gene, HBB, located on the 16th chromosome. Thalassemia is a quantitative problem due to deletion of HBA1 or HBA2 genes of 16th chromosome. HBB gene is on 11th chromosome.

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