HDNB can be prevented by administering

Erythroblastosis foetalis or Haemolytic Disorder of Newborn (HDNB) can be avoided by administering anti-Rh antibodies to the mother immediately after the delivery of the first child. Rh incompatibility is observed between the ${\mathrm{Rh}}^{-\mathrm{ve}}$ blood of a pregnant mother with ${\mathrm{Rh}}^{+\mathrm{ve}}$ blood of the foetus. Rh antigens of the foetus do not get exposed to the ${\mathrm{Rh}}^{-\mathrm{ve}}$ blood of the mother in the first pregnancy as the two bloods are well separated by the placenta. During the delivery of the first child, there is a possibility of exposure of the maternal blood to small amounts of the ${\mathrm{Rh}}^{+\mathrm{ve}}$ blood from the foetus. In such cases, the mother starts preparing antibodies against Rh antigen in her blood. In case of her subsequent pregnancies, the Rh antibodies from the mother (${\mathrm{Rh}}^{-\mathrm{ve}}$) can leak into the blood of the foetus (${\mathrm{Rh}}^{+\mathrm{ve}}$) and destroy the foetal RBCs. This could be fatal to the foetus or could cause severe anaemia and jaundice to the baby, which is termed HDNB.