How many of the following features are applicable to the hormones?

i. Non-nutrient chemicals
ii. Intracellular messengers
iii. Released in blood or open spaces
iv. Produced in trace amounts

Hormones are non-nutrient chemicals which act as intercellular messengers and are produced in trace amounts. They are produced by endocrine glands and released into the blood or open spaces (in animals with open type of circulatory system) and transported to a distantly located target organ.