How many of these statements given below are true?

(A) tRNA is a compact molecule with inverted ‘L’ shape.

(B) Amino acylation of tRNA requires ATP.

(C) The reading frame does not change from the point where the insertion or deletion of three or multiple of three bases occur.

(D) There are no tRNAs for stop codons

(A) True. tRNA (transfer RNA) is indeed a compact molecule with an inverted 'L' shape. This shape is due to the presence of stem-loop structures within the tRNA molecule.

(B) True. The aminoacylation of tRNA, which involves attaching an amino acid to the tRNA molecule, requires the energy molecule adenosine triphosphate (ATP). This process is catalyzed by aminoacyl-tRNA synthetases.

(C) True. The reading frame in protein synthesis does not change from the point where an insertion or deletion of three or its multiple bases occurs. This is because the genetic code is read in triplets, with each codon specifying a specific amino acid. Insertions or deletions of bases that are not multiples of three would result in a frameshift mutation, causing a significant change in the reading frame and subsequent amino acid sequence.

(D) True. There are no tRNAs (transfer RNAs) for stop codons. Stop codons (UAA, UAG, and UGA in the standard genetic code) signal the termination of protein synthesis, and there are no corresponding tRNAs that carry amino acids to insert at these codons. Instead, release factors recognize stop codons and help terminate translation.

Therefore, all the given statements (A, B, C, and D) are true.