I. Thermoregulation, osmoregulation and excretion are mechanisms that moderate change in the body.
II. 99% animals and almost all plants are conformers 
III. Heat loss or heat gain is a function of surface area.
IV. Thermoregulation energetically least expensive process for many organisms like shrews and humming birds
V. 99% animals are thermoregulators
VI. Archaebacteria cannot tolerate high temperature