Identify incorrect statement about enzyme catalysis is

1.Highly efficient catalysts

2.With temperature rate of reaction increases but not monotonic. It reaches a maximum value and then decreases. The temperature at which rate is maximum is known as optimum temperature. In human body it is between 25⁰C and 37⁰C 

3. Enzyme contains both basic and acidic centres rate of reaction depends of P^H of the solution.Rate is maximum at an optimum P^H range of 5 - 7

4.Highly specific in their selection of substrates, no side reactions in enzyme catalysed reaction