If all the TSH receptors are removed from the thyroid gland,

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TSH would start stimulating other endocrine glands

The thyroid would respond only to a higher concentration of TSH

The pituitary would stop producing TSH

TSH cannot stimulate the thyroid gland

answer is D.

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Detailed Solution

Hormones produce their effects on target tissues by binding to specific proteins called hormone receptors located in the target tissues only. If hormone receptors are removed from a target gland, it cannot respond to the hormone. So if TSH receptors are removed, TSH cannot stimulate the thyroid to produce thyroxine.

TSH cannot stimulate other endocrine glands because they lack TSH receptors.

Even a higher concentration of TSH also cannot stimulate the thyroid if TSH receptors are totally absent.

In the absence of negative feedback by the blood levels of thyroxine, the pituitary continues to produce TSH.

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