If the pH in lysosomes is increased to alkaline, what will be the outcome? 

When the pH in lysosomes becomes alkaline, the hydrolytic enzymes lose their optimal acidic environment and become
inactive or less effi cient. 
(1) Hydrolytic enzymes in lysosomes function optimally at an acidic pH, and if the pH becomes alkaline, their activity
will decrease or become inactive. 
(3) There is no indication that the change in pH would cause lysosomal enzymes to be released into the cytoplasm. The
primary consequence is the inactivation of the enzymes.
(4) Alkaline pH is not favourable for the activity of lysosomal enzymes; it hinders their normal functioning.