In Griffith experiment, what would be the effect of following conditions on mice?

Form of Pneumococcas Injected	Effect on Mice
I. Live R-strain	A
II. Live S-strain	B
III. Heat-killed S-strain	C
IV. Heat-killed S-strain + live R-strain	D

Choose the correct option for effect on mice.

When Streptococcus pneumoniae (pneumococcus) bacteria are grown on a culture plate, some produce smooth shiny colonies (S) while others produce rough colonies (R). This is because the S strain bacteria have a mucous (polysaccharide) coat, while R strain does not. Mice infected with the S strain (virulent) die from pneumonia infection but mice infected with the R strain do not develop pneumonia. Griffith was able to kill bacteria by heating them. He observed that heat-killed S strain bacteria injected into mice did not kill them. When he injected heat killed S strain and live R train bacteria the mice died ,because of transferring transforming principle from S strain to R strain bacteria .