In sickle cell anaemia, where amino acid modification occurs in $β$ -chain?

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Valine $\to$ Glutamate

Threonine $\to$ Valine

Tyrosine $\to$ Glutamate

Glutamate $\to$ Valine

answer is D.

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Detailed Solution

In sickle cell anemia, a thymine (T) nucleotide is substituted for an adenine (A) nucleotide at position 6 of the beta-globin gene's coding sequence. This results in a change from the normal codon GAG (encoding the amino acid glutamic acid) to GUG, which codes for the amino acid valine.

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