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Q.

In sickle cell anaemia, which amino acid modification occurs in the β -chain of amino acid?

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a

Threonine → Valine

b

Tyrosine → Glutamate

c

Valine → Glutamate

d

Glutamate → Valine

answer is D.

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Detailed Solution

A classical example of point mutation is a change of single base pair in the gene for beta globin chain that results in the change of amino acid residue glutamate to valine.

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