Q.

In which of the following steps of Kreb’s cycle, decarboxylation occurs.
A) Pyruvate  Acetyl CoA
B) Citric acid  Keto glutaric acid 
C) Alpha Keto glutarate  Succinic Acid
D) Malic acid Oxaloacetic  Acid

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a

B and C

b

A and D

c

B, C and D

d

A, B and C             

answer is B.

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Detailed Solution

Decarboxylation takes place when citric acid (^C) is converted to alpha keto glutaric acid (5C) and when alpha keto glutaric acid (5C) is converted to succinyl CoA (4C) during kreb cycle.

Though conversion of pyruvic acid to acetyl CoA also requires decarboxylation but it is not a part of Kreb cycle.

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In which of the following steps of Kreb’s cycle, decarboxylation occurs.A) Pyruvate → Acetyl CoAB) Citric acid →→ Keto glutaric acid C) Alpha Keto glutarate → Succinic AcidD) Malic acid →Oxaloacetic  Acid