Mention any two autosomal genetic disorders with their symptoms.

Down’s syndrome:

• It is caused due to presence of extra chromosome in 21st set (Trisomy 21).
• The affected individuals are with small head, partially open mouth, furrowed tongue.
• Physical and intellectual development is slow.

Edward’s syndrome: 

• It is caused due to extra chromosome in 18^th set (Trisomy18).
• It is more common in female offspring.
• Majority die in foetal stage. Infant who survives has serious defects in heart and liver and die at early age.