Q.

Observe the given picture and choose correct set.

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(a) A and B chains are connected by disulphide bonds 

(b) It is mature insulin 

(c) C peptide is not a part of it 

(d) It is a prohormone which needs to be processed inorder to become a functional hormone.

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a

a, d

b

a, c, d

c

only d

d

b, c

answer is A.

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Detailed Solution

In mammals, including humans, insulin is synthesised as a pro-hormone (like a pro-enzyme, the pro-hormone also needs to be processed before it becomes a fully mature and functional hormone) which contains an extra stretch called the C peptide. This C peptide is not present in the mature insulin and is removed during maturation into insulin.

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