Q.

Oxidative decarboxylation is observed in which step of aerobic respiration?

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a

Conversion of succinic acid to fumaric acid

b

Conversion of oxaloacetic acid to citric acid

c

Conversion of phosphoenolpyruvate to pyruvic acid

d

Conversion of pyruvic acid to acetyl CoA

answer is D.

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Detailed Solution

Pyruvate, which is formed by the glycolytic catabolism of carbohydrates in the cytosol, enters into mitochondrial matrix and undergoes oxidative decarboxylation by a complex set of reactions catalysed by pyruvic dehydrogenase. The reactions catalysed by pyruvic dehydrogenase requires the participation of several coenzymes, including NAD+ and Coenzyme A.

Pyruvic acid+CoA+NAD+Pyruvate dehydrogenaseMg2Acetyl CoA+CO2+NADH+H+

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