Progressive degeneration of skeletal muscle is mostly due to a genetic disorder called

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myasthenia gravis

rheumatoid arthritis

muscular dystrophy

achondroplasia

answer is C.

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Detailed Solution

Progressive degeneration of skeletal muscle is primarily associated with genetic disorders known as muscular dystrophies. Muscular dystrophies are a group of inherited conditions characterised by the gradual weakening and wasting of muscles over time. These disorders are caused by genetic mutations that interfere with the production or function of specific proteins necessary for maintaining the structure and stability of muscle fibers. The most well-known and common type of muscular dystrophy is Duchenne muscular dystrophy (DMD), which is caused by a mutation in the DMD gene that codes for the protein dystrophin.
Myasthenia gravis is an autoimmune disorder of neuromuscular junction.
Rheumatoid arthritis is an autoimmune disorder of joints.
Achondroplasia is a bone growth disorder that causes disproportionate dwarfism.

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