Proteolytic enzymes are produced in the form of an inactive precursor called proenzymes or zymogens. The proenzyme is subsequently cleaved to yield the active form. Why are these enzymes not produced directly in active form?

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ATP is needed for the activation of the enzyme

If secreted in active form, the enzymes would destroy the cells synthesizing them

Proenzymes are smaller and hence are easily transported across the cell membrane

ATP is not needed for the synthesis of proenzymes, unlike in the case of enzymes

answer is B.

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Detailed Solution

If secreted in active form, the enzymes would destroy the cells synthesizing them. Activation occurs only after they are released into the lumen of the gut. ATP is needed for the synthesis of proenzyme but not for its activation. The proenzyme is longer than the active enzyme and has extra sequence of amino acids which is subsequently cleaved to yield the active form.

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