Q.

Sickle cell anaemia is 

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a

characterised by elongated, nucleated sickle like RBCs. 

b

caused due to substitution of valine by glutamic acid.

c

an autosomal dominant trait.

d

a classic example for point mutation.

answer is D.

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Detailed Solution

A classical example of point mutation is sickle cell anemia. A point mutation is a change of a single base pair in DNA.

It is an autosomal recessive trait.

It is caused due to substitution of glutamic acid by valine.

It is characterised by elongated, enucleated sickle like RBCs. 

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Sickle cell anaemia is