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Q.

Read the following statements.
(a) It is an autosome-linked recessive blood disease.
(b) It causes the formation of abnormal haemoglobin molecules, resulting in anaemia.
(c) It is a quantitative problem.
(d) It is controlled by two closely linked genes on chromosome 16.
The above features are applicable to

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a

Phenylketonuria

b

Haemophilia

c

Cystic fibrosis

d

$α$ -thalassemia

answer is D.

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Detailed Solution

The features explained are related to α-thalassemia. In α-thalassemia, production of a globin chain is
affected. It is an autosome-linked recessive blood disease which is controlled by two closely linked genes HBA1 and HBA2 on chromosome 16 of each parent. It is a quantitative problem.

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