Rejection of grafted kidney in a patient is mainly due to

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humoral immune response

passive immune response

cell-mediated immune response

innate immune response

answer is D.

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Detailed Solution

When a kidney is transplanted from one individual to another, the recipient’s immune system recognises the transplanted kidney as foreign and mounts an immune response to reject the transplanted kidney.
The rejection is mainly due to cell-mediated immune responses.

(1) Passive immune response is brought about the pre-formed antibodies transferred from another individual, and it is not involved in transplant rejection.

(2) Graft rejection is due to cell mediated immunity, which is a component of adaptive immunity not innate immunity.

(3) Humoral immune response is mediated by antibodies, which are not the primary mediators of rejection. Cell-mediated immunity is the main mechanism by which the transplanted organ is rejected.

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