Select incorrect statement, regarding chemical structure of insulin.

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Polypeptide chains A and B are linked by disulphide bridges

Mature insulin molecule consists of three polypeptide chains-A, B and C.

Insulin is synthesized as prohormo ne which contains extra stretch of C-peptide.

C-peptide is not present in mature insulin molecule.

answer is A.

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Detailed Solution

Mature insulin consists of only two polypeptide chains: A-peptide and B-peptide.
(2) Insulin is synthesized as a prohormone, called proinsulin, which is the precursor molecule that contains an extra stretch of C-peptide, in addition to A-peptide and B-peptide.
(3) C-peptide is not present in mature insulin. It is present in the proinsulin molecule (precursor of insulin). During
The process of maturation, proinsulin is cleaved, resulting in the removal of C-peptide.
(4) Polypeptides A and B are linked by disulphide bridges (A7-B7 and A20-B19). These disulphide bonds contribute to
the stable structure of insulin.

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