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Estradiol - Intracellular receptor

Insulin - Intracellular receptor

Progesterone - Surface receptor

Cortisol - Surface receptor

answer is A.

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Detailed Solution

Estradiol: Estradiol is a steroid hormone and belongs to the class of estrogens. Steroid hormones are derived from cholesterol and are characterized by their four-ring structure. It binds to intracellular receptor.
Insulin: Insulin is a peptide hormone. Peptide hormones are composed of amino acids and are usually water-soluble. They often bind to cell surface receptors.
Progesterone: Progesterone is a steroid hormone and belongs to the class of progestogens. Like estradiol, it is also derived from cholesterol and has a four-ring structure. It binds to intracellular receptor.
Cortisol: Cortisol is a steroid hormone and belongs to the class of glucocorticoids. It is also derived from cholesterol and has a four-ring structure. It binds to intracellular receptor.

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