Select the correct difference between sickle-cell anaemia and thalassemia.
Sickle cell anaemia Thalassemia
1. Quantitative problem Qualitative problem
2. Incorrectly functioning haemoglobin is synthesised Too many haemoglobin molecules are synthesised
3. Controlled by two genes Controlled by a single gene
4. Beta chain is affected Alpha or beta chain is affected

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answer is D.

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Detailed Solution

Thalassemia is of two types - alpha thalassemia and beta thalassemia depending on the globin chain affected.

Sickle cell anaemia	Thalassemia
Qualitative problem	Quantitative problem
Incorrectly functioning haemoglobin is synthesised	Very few haemoglobin molecules are synthesised
Controlled by a single gene (HBB)	Controlled by two genes (HBA or HBB)
Beta chain is affected	Alpha or beta chain is affected

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